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DESCRIPTION:Mapping the Brain\n\nBy Dr. Rui Costa\, PhD\, President and Chi
 ef Executive Officer\, Allen Institute\n\nPresentation will be held at the
  McIntyre Medical Building (3655 Promenade Sir-William0Osler)\, room 522\n
 \nThis talk will be followed by a wine and cheese reception in the lobby o
 f the McIntyre Medical building.\n\nAn informal seminar will also be given
  by Dr. Costa at 10:00am in room 461 of 2001 av ´ó·¢²ÊƱƽ̨ College.\n\nAbstrac
 t:\n\nThe ability of animals to build individual repertoires based on the 
 consequences of their actions is fascinating\, and essential for survival.
  Understanding this process (i.e.\, how actions are learned through trial 
 and feedback) requires mechanistic insight into how self-paced actions are
  initiated\, how they can be selected/initiated again\, and how feedback c
 an refine their execution and organization. We use behavioral\, genetic\, 
 electrophysiological\, and optical approaches to gain this mechanistic ins
 ight. The combination of these approaches allowed us to uncover that dopam
 inergic neurons are transiently active before self-paced movement initiati
 on. This activity is not action-specific and modulates both the probabilit
 y of initiation and the vigor of future movements but does not affect ongo
 ing movement. Dopamine is supposed to have opposite effects on downstream 
 striatal direct and indirect pathways. Contrary to what is classically pos
 tulated\, we found that both striatal direct and indirect pathways are act
 ive during movement initiation. The activity in both pathways is action-sp
 ecific and has complementary but different roles in movement\, which are e
 nabled by specific basal ganglia output circuits. Input from cortex seems 
 to be critical to organize striatal activity\, and cortico-striatal plasti
 city is necessary to select\, reinforce and refine the specific neural and
  behavioral patterns that lead to desirable outcomes. These data invite ne
 w models on the mechanisms underlying self-paced movement initiation\, and
  motor dysfunction in Parkinson’s disease. They also suggest that cortico-
 basal ganglia circuits play a generic role in learning to reinforce and re
 fine task-relevant neural activity and behavioral patterns.\n
DTSTART:20250207T203000Z
DTEND:20250207T220000Z
SUMMARY:Bindra Lecture
URL:/psychiatry/channels/event/bindra-lecture-362548
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