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UID:20250512T092532EDT-1166p0xdgU@132.216.98.100
DTSTAMP:20250512T132532Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and ´ó·¢²ÊƱƽ̨ Univers
 ity.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, clic
 k here\n\n\nMartin Lévesque\n\nProfessor\, Department of Psychiatry and Ne
 urosciences\, Laval University\n\nHost: j-francois.poulin [at] mcgill.ca (
 Jean-Francois Poulin)\n\nAbstract: Parkinson's disease (PD) is characteriz
 ed by the progressive loss of dopaminergic neurons in the substantia nigra
 \, leading to motor dysfunction. While the exact cause of PD remains uncle
 ar\, mitochondrial dysfunction and the accumulation of toxic protein aggre
 gates are thought to play central roles in neuronal death. This presentati
 on discusses two promising neuroprotective strategies. First\, a CRISPR-ba
 sed genetic screen identified Ligase IV (Lig4)\, a DNA repair protein\, as
  critical for dopaminergic neuron survival. Notably\, Lig4 knockout protec
 ted neurons from rotenone-induced toxicity in vitro and against neurodegen
 eration in PD mouse models. Second\, the presentation highlights the use o
 f mini-antibodies targeting α-synuclein\, which prevent the spread of path
 ology and the onset of motor dysfunction in a PD mouse model. These findin
 gs provide new therapeutic avenues for protecting neurons and potentially 
 modifying disease progression in PD.\n
DTSTART:20241210T210000Z
DTEND:20241210T220000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Novel Approaches Against Neurodegeneration: 
 From Genetic Screens to Antibody-Based Therapeutics
URL:/neuro/channels/event/killam-seminar-series-novel-
 approaches-against-neurodegeneration-genetic-screens-antibody-based-361103
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