BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250508T042230EDT-29595kvvI6@132.216.98.100
DTSTAMP:20250508T082230Z
DESCRIPTION:La série Feindel Brain and Mind Seminar s’inscrit dans la ligne
  de pensée du Dr William Feindel (1918-2014)\, directeur du Neuro de 1972 
 à 1984\, qui consiste à maintenir un lien constant entre pratique clinique
  et recherche. Les présentations porteront sur les dernières avancées et d
 écouvertes en neuropsychologie\, en neurosciences cognitives et en neuro-i
 magerie. \n\nLes scientifiques du Neuro\, ainsi que des collègues et colla
 borateurs venus du milieu ou du monde entier\, se chargeront des conférenc
 es. Cette série se veut un forum virtuel pour les chercheurs et les stagia
 ires en vue de favoriser les échanges interdisciplinaires sur les mécanism
 es des troubles cérébraux et cognitifs\, leur diagnostic et leur traitemen
 t. \n\n\nPour assister en personne\, inscrivez-vous ici\n\nPour regarder v
 ia Vimeo\,\n\n\nLydia Chougar\n\nPost-doctoral fellow\, The Neuro\, ´ó·¢²ÊƱƽ̨
  University\n\nHôte: \n\nAbstract: \n\nParkinson’s disease\, the second mo
 st common neurodegenerative disease after Alzheimer’s disease\, is the mai
 n cause of Parkinsonism\, which is defined by a combination of resting tre
 mor\, rigidity\, bradykinesia\, and postural instability. Atypical Parkins
 onism refers to other rare neurodegenerative disorders characterized by a 
 poorer diagnosis\, including progressive supranuclear palsy (PSP)\, multip
 le system atrophy (MSA)\, and corticobasal degeneration. Degeneration of t
 he substantia nigra pars compacta is the pathological hallmark of neurodeg
 enerative Parkinsonian disorders. These diseases present significant chall
 enges in terms of early diagnosis\, differentiation\, and understanding of
  pathophysiology.\n\nNeuroimaging has profoundly changed the landscape of 
 research and clinical management of Parkinsonism over the past twenty-five
  years. Magnetic resonance imaging (MRI) provides several in vivo quantita
 tive biomarkers sensitive to different tissue properties that inform about
  the underlying pathological processes. Regional brain atrophy\, detected 
 using T1-weighted three-dimensional (3D) sequences\, reflects neuronal los
 s. Diffusion anomalies indicate the presence of microstructural alteration
 s in the tissues related to neuroinflammation\, while iron-sensitive imagi
 ng detects iron deposits. Neuromelanin-sensitive MRI serves as a proxy for
  the degeneration of the substantia nigra. More recently\, positron emissi
 on tomography (PET) has specifically allowed for the detection of misfolde
 d protein aggregates\, such as Tau and alpha-synuclein\, observed in these
  diseases\, giving access to an ante-mortem pathological diagnosis.\n\nIn 
 the first part of my talk\, I will illustrate how neuroimaging biomarkers 
 contribute to a better understanding of the pathophysiology of Parkinson’s
  disease and how they can be used to provide an early diagnosis\, quantify
  disease severity and progression\, and monitor treatment effects. The sec
 ond part will highlight the contribution of neuroimaging to the differenti
 al diagnosis of Parkinsonian disorders\, with a focus on the recent applic
 ations of machine learning algorithms trained with MRI features.\n
DTSTART:20240916T170000Z
DTEND:20240916T180000Z
LOCATION:De Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Seminar Series: Contribution of MRI to the u
 nderstanding and diagnosis of Parkinsonism
URL:/neuro/fr/channels/event/feindel-brain-and-mind-se
 minar-series-contribution-mri-understanding-and-diagnosis-parkinsonism-359
 425
END:VEVENT
END:VCALENDAR